Variant dossier
ALK p.R1275L
Static provenance dossier for a highlighted variant. Use the linked Explore state to compare related records across the full catalog.
DriverHotspotActionable
ALK p.R1275L
No mechanism summary is present in the seed catalog for this record.
Not reported
18
1
- Coordinate
- No coordinate
- Cancer types
- Not reported
- Pathway
- RTK-RAS
- Therapy context
- Alectinib, Crizotinib, Ceritinib, Brigatinib, Lorlatinib
- Clinical annotation
- N/A
- Citations
- CancerHotspots:ALK:R1275
| Variant | Cancer | Evidence | Frequency | Sources |
|---|---|---|---|---|
| BRAF p.V600E | THPA | DriverHotspotActionable | 58.0% | cBioPortal, TCGA Pan-Cancer Atlas |
| BRAF p.V600E | SKCM | DriverHotspotActionable | 35.9% | cBioPortal, TCGA Pan-Cancer Atlas |
| KRAS p.G12D | PAAD | DriverHotspotActionable | 27.4% | cBioPortal, TCGA Pan-Cancer Atlas |
| KRAS p.G12C | LUAD | DriverHotspotActionable | 12.4% | cBioPortal, TCGA Pan-Cancer Atlas |
| KRAS p.G12V | PAAD | DriverHotspotActionable | 18.4% | cBioPortal, TCGA Pan-Cancer Atlas |
| KRAS p.G12D | COADREAD | DriverHotspotActionable | 10.9% | cBioPortal, TCGA Pan-Cancer Atlas |
| KRAS p.G12V | COADREAD | DriverHotspotActionable | 9.2% | cBioPortal, TCGA Pan-Cancer Atlas |
| BRAF p.V600E | COADREAD | DriverHotspotActionable | 9.0% | cBioPortal, TCGA Pan-Cancer Atlas |