Variant dossier
ERBB2 p.R678Q
Static provenance dossier for a highlighted variant. Use the linked Explore state to compare related records across the full catalog.
DriverHotspotActionable
ERBB2 p.R678Q
No mechanism summary is present in the seed catalog for this record.
0.92%
4
2
- Coordinate
- GRCh37 chr17:37,879,658
- Cancer types
- STAD Stomach Adenocarcinoma (TCGA, PanCancer Atlas)
- Pathway
- RTK-RAS
- Therapy context
- Trastuzumab, Pertuzumab, Lapatinib, Neratinib, Tucatinib
- Clinical annotation
- N/A
- Citations
- 29625048, 29596782, 29622463, 29617662, 29625055, 29625050, 32214244, 29625049, 29850653, 36334560
| Variant | Cancer | Evidence | Frequency | Sources |
|---|---|---|---|---|
| BRAF p.V600E | THPA | DriverHotspotActionable | 58.0% | cBioPortal, TCGA Pan-Cancer Atlas |
| BRAF p.V600E | SKCM | DriverHotspotActionable | 35.9% | cBioPortal, TCGA Pan-Cancer Atlas |
| KRAS p.G12D | PAAD | DriverHotspotActionable | 27.4% | cBioPortal, TCGA Pan-Cancer Atlas |
| KRAS p.G12C | LUAD | DriverHotspotActionable | 12.4% | cBioPortal, TCGA Pan-Cancer Atlas |
| KRAS p.G12V | PAAD | DriverHotspotActionable | 18.4% | cBioPortal, TCGA Pan-Cancer Atlas |
| KRAS p.G12D | COADREAD | DriverHotspotActionable | 10.9% | cBioPortal, TCGA Pan-Cancer Atlas |
| KRAS p.G12V | COADREAD | DriverHotspotActionable | 9.2% | cBioPortal, TCGA Pan-Cancer Atlas |
| BRAF p.V600E | COADREAD | DriverHotspotActionable | 9.0% | cBioPortal, TCGA Pan-Cancer Atlas |