Variant dossier
KIT p.D816Y
Static provenance dossier for a highlighted variant. Use the linked Explore state to compare related records across the full catalog.
DriverHotspotActionable
KIT p.D816Y
No mechanism summary is present in the seed catalog for this record.
0.50%
1
2
- Coordinate
- GRCh37 chr4:55,599,320
- Cancer types
- AML Acute Myeloid Leukemia (TCGA, PanCancer Atlas)
- Pathway
- RTK-RAS
- Therapy context
- Imatinib, Sunitinib, Avapritinib
- Clinical annotation
- N/A
- Citations
- 29625048, 29596782, 29622463, 29617662, 29625055, 29625050, 32214244, 29625049, 29850653, 36334560
| Variant | Cancer | Evidence | Frequency | Sources |
|---|---|---|---|---|
| BRAF p.V600E | THPA | DriverHotspotActionable | 58.0% | cBioPortal, TCGA Pan-Cancer Atlas |
| BRAF p.V600E | SKCM | DriverHotspotActionable | 35.9% | cBioPortal, TCGA Pan-Cancer Atlas |
| KRAS p.G12D | PAAD | DriverHotspotActionable | 27.4% | cBioPortal, TCGA Pan-Cancer Atlas |
| KRAS p.G12C | LUAD | DriverHotspotActionable | 12.4% | cBioPortal, TCGA Pan-Cancer Atlas |
| KRAS p.G12V | PAAD | DriverHotspotActionable | 18.4% | cBioPortal, TCGA Pan-Cancer Atlas |
| KRAS p.G12D | COADREAD | DriverHotspotActionable | 10.9% | cBioPortal, TCGA Pan-Cancer Atlas |
| KRAS p.G12V | COADREAD | DriverHotspotActionable | 9.2% | cBioPortal, TCGA Pan-Cancer Atlas |
| BRAF p.V600E | COADREAD | DriverHotspotActionable | 9.0% | cBioPortal, TCGA Pan-Cancer Atlas |