Variant dossier
PIK3CA p.H1047L
Static provenance dossier for a highlighted variant. Use the linked Explore state to compare related records across the full catalog.
DriverHotspotActionable
PIK3CA p.H1047L
No mechanism summary is present in the seed catalog for this record.
2.8%
1
2
- Coordinate
- GRCh37 chr3:178,952,085
- Cancer types
- CHOL Cholangiocarcinoma (TCGA, PanCancer Atlas)
- Pathway
- PI3K-AKT
- Therapy context
- Alpelisib
- Clinical annotation
- N/A
- Citations
- 29625048, 29596782, 29622463, 29617662, 29625055, 29625050, 32214244, 29625049, 29850653, 36334560
| Variant | Cancer | Evidence | Frequency | Sources |
|---|---|---|---|---|
| PIK3CA p.H1047R | BRCA | DriverHotspotActionable | 12.1% | cBioPortal, TCGA Pan-Cancer Atlas |
| PIK3CA p.E545K | CESC | DriverHotspotActionable | 12.7% | cBioPortal, TCGA Pan-Cancer Atlas |
| PIK3CA p.E545K | BRCA | DriverHotspotActionable | 6.1% | cBioPortal, TCGA Pan-Cancer Atlas |
| PIK3CA p.E542K | BRCA | DriverHotspotActionable | 4.0% | cBioPortal, TCGA Pan-Cancer Atlas |
| PIK3CA p.R88Q | UCEC | DriverHotspotActionable | 7.0% | cBioPortal, TCGA Pan-Cancer Atlas |
| PIK3CA p.E545K | COADREAD | DriverHotspotActionable | 6.6% | cBioPortal, TCGA Pan-Cancer Atlas |
| PIK3CA p.E545K | BLCA | DriverHotspotActionable | 7.1% | cBioPortal, TCGA Pan-Cancer Atlas |
| PIK3CA p.H1047R | UCEC | DriverHotspotActionable | 5.6% | cBioPortal, TCGA Pan-Cancer Atlas |