Variant dossier
PIK3CA p.P447_L455del
Static provenance dossier for a highlighted variant. Use the linked Explore state to compare related records across the full catalog.
DriverHotspotActionable
PIK3CA p.P447_L455del
No mechanism summary is present in the seed catalog for this record.
0.28%
3
2
- Coordinate
- GRCh37 chr3:178,928,060
- Cancer types
- BRCA Breast Invasive Carcinoma (TCGA, PanCancer Atlas)
- Pathway
- PI3K-AKT
- Therapy context
- Alpelisib
- Clinical annotation
- N/A
- Citations
- 29625048, 29596782, 29622463, 29617662, 29625055, 29625050, 30643250, 32214244, 29625049, 29850653 +1
| Variant | Cancer | Evidence | Frequency | Sources |
|---|---|---|---|---|
| PIK3CA p.H1047R | BRCA | DriverHotspotActionable | 12.1% | cBioPortal, TCGA Pan-Cancer Atlas |
| PIK3CA p.E545K | CESC | DriverHotspotActionable | 12.7% | cBioPortal, TCGA Pan-Cancer Atlas |
| PIK3CA p.E545K | BRCA | DriverHotspotActionable | 6.1% | cBioPortal, TCGA Pan-Cancer Atlas |
| PIK3CA p.E542K | BRCA | DriverHotspotActionable | 4.0% | cBioPortal, TCGA Pan-Cancer Atlas |
| PIK3CA p.R88Q | UCEC | DriverHotspotActionable | 7.0% | cBioPortal, TCGA Pan-Cancer Atlas |
| PIK3CA p.E545K | COADREAD | DriverHotspotActionable | 6.6% | cBioPortal, TCGA Pan-Cancer Atlas |
| PIK3CA p.E545K | BLCA | DriverHotspotActionable | 7.1% | cBioPortal, TCGA Pan-Cancer Atlas |
| PIK3CA p.H1047R | UCEC | DriverHotspotActionable | 5.6% | cBioPortal, TCGA Pan-Cancer Atlas |