Cancer slice
Breast Invasive Carcinoma (TCGA, PanCancer Atlas)
300 records, 69 actionable signals, and 296 hotspot records in this source-aligned cancer slice.
| Variant | Cancer | Evidence | Frequency | Sources |
|---|---|---|---|---|
| PIK3CA p.H1047R | BRCA | DriverHotspotActionable | 12.1% | cBioPortal, TCGA Pan-Cancer Atlas |
| PIK3CA p.E545K | BRCA | DriverHotspotActionable | 6.1% | cBioPortal, TCGA Pan-Cancer Atlas |
| PIK3CA p.E542K | BRCA | DriverHotspotActionable | 4.0% | cBioPortal, TCGA Pan-Cancer Atlas |
| PIK3CA p.N345K | BRCA | DriverHotspotActionable | 1.7% | cBioPortal, TCGA Pan-Cancer Atlas |
| PIK3CA p.H1047L | BRCA | DriverHotspotActionable | 1.2% | cBioPortal, TCGA Pan-Cancer Atlas |
| PIK3CA p.E726K | BRCA | DriverHotspotActionable | 0.94% | cBioPortal, TCGA Pan-Cancer Atlas |
| PIK3CA p.G118D | BRCA | DriverHotspotActionable | 0.56% | cBioPortal, TCGA Pan-Cancer Atlas |
| PIK3CA p.Q546R | BRCA | DriverHotspotActionable | 0.56% | cBioPortal, TCGA Pan-Cancer Atlas |
| PIK3CA p.E545A | BRCA | DriverHotspotActionable | 0.56% | cBioPortal, TCGA Pan-Cancer Atlas |
| PIK3CA p.E453K | BRCA | DriverHotspotActionable | 0.56% | cBioPortal, TCGA Pan-Cancer Atlas |
| ERBB2 p.L755S | BRCA | DriverHotspotActionable | 0.47% | cBioPortal, TCGA Pan-Cancer Atlas |
| PIK3CA p.C420R | BRCA | DriverHotspotActionable | 0.47% | cBioPortal, TCGA Pan-Cancer Atlas |
| PIK3CA p.Q546K | BRCA | DriverHotspotActionable | 0.38% | cBioPortal, TCGA Pan-Cancer Atlas |
| ERBB2 p.V777L | BRCA | DriverHotspotActionable | 0.28% | cBioPortal, TCGA Pan-Cancer Atlas |
| KRAS p.G12V | BRCA | DriverHotspotActionable | 0.28% | cBioPortal, TCGA Pan-Cancer Atlas |
| PIK3CA p.P447_L455del | BRCA | DriverHotspotActionable | 0.28% | cBioPortal, TCGA Pan-Cancer Atlas |
| ERBB2 p.D769Y | BRCA | DriverHotspotActionable | 0.19% | cBioPortal, TCGA Pan-Cancer Atlas |
| ERBB2 p.I767M | BRCA | DriverHotspotActionable | 0.19% | cBioPortal, TCGA Pan-Cancer Atlas |
| FGFR2 p.N549K | BRCA | DriverHotspotActionable | 0.19% | cBioPortal, TCGA Pan-Cancer Atlas |
| PIK3CA p.R88Q | BRCA | DriverHotspotActionable | 0.19% | cBioPortal, TCGA Pan-Cancer Atlas |
| PIK3CA p.H1047Y | BRCA | DriverHotspotActionable | 0.19% | cBioPortal, TCGA Pan-Cancer Atlas |
| PIK3CA p.G1049R | BRCA | DriverHotspotActionable | 0.19% | cBioPortal, TCGA Pan-Cancer Atlas |
| PIK3CA p.M1043I | BRCA | DriverHotspotActionable | 0.19% | cBioPortal, TCGA Pan-Cancer Atlas |
| PIK3CA p.E110del | BRCA | DriverHotspotActionable | 0.19% | cBioPortal, TCGA Pan-Cancer Atlas |
| PIK3CA p.E545G | BRCA | DriverHotspotActionable | 0.19% | cBioPortal, TCGA Pan-Cancer Atlas |
| PIK3CA p.R108H | BRCA | DriverHotspotActionable | 0.19% | cBioPortal, TCGA Pan-Cancer Atlas |
| PIK3CA p.M1004I | BRCA | DriverHotspotActionable | 0.19% | cBioPortal, TCGA Pan-Cancer Atlas |
| PIK3CA p.E542G | BRCA | DriverHotspotActionable | 0.19% | cBioPortal, TCGA Pan-Cancer Atlas |
| PIK3CA p.K111del | BRCA | DriverHotspotActionable | 0.19% | cBioPortal, TCGA Pan-Cancer Atlas |
| PIK3CA p.G1007R | BRCA | DriverHotspotActionable | 0.19% | cBioPortal, TCGA Pan-Cancer Atlas |
| PIK3CA p.N1044Y | BRCA | DriverHotspotActionable | 0.19% | cBioPortal, TCGA Pan-Cancer Atlas |
| PIK3CA p.D939G | BRCA | DriverHotspotActionable | 0.19% | cBioPortal, TCGA Pan-Cancer Atlas |
| ERBB2 p.L755M | BRCA | DriverHotspotActionable | 0.09% | cBioPortal, TCGA Pan-Cancer Atlas |
| ERBB2 p.L755W | BRCA | DriverHotspotActionable | 0.09% | cBioPortal, TCGA Pan-Cancer Atlas |
| ERBB2 p.R678Q | BRCA | DriverHotspotActionable | 0.09% | cBioPortal, TCGA Pan-Cancer Atlas |
| ERBB2 p.S310F | BRCA | DriverHotspotActionable | 0.09% | cBioPortal, TCGA Pan-Cancer Atlas |
| ERBB2 p.V842I | BRCA | DriverHotspotActionable | 0.09% | cBioPortal, TCGA Pan-Cancer Atlas |
| ERBB2 p.V777L | BRCA | DriverHotspotActionable | 0.09% | cBioPortal, TCGA Pan-Cancer Atlas |
| ALK p.R1275* | BRCA | DriverHotspotActionable | 0.09% | cBioPortal, TCGA Pan-Cancer Atlas |
| ERBB2 p.D769H | BRCA | DriverHotspotActionable | 0.09% | cBioPortal, TCGA Pan-Cancer Atlas |