Cancer slice

Brain Lower Grade Glioma (TCGA, PanCancer Atlas)

391 records, 80 actionable signals, and 389 hotspot records in this source-aligned cancer slice.

Variant	Cancer	Evidence	Frequency	Sources
IDH1 p.R132H substitution	DIFG	DriverHotspotActionable	69.6%	TCGA Pan-Cancer Atlas, cBioPortal
IDH1 p.R132C substitution	DIFG	DriverHotspotActionable	3.3%	TCGA Pan-Cancer Atlas, cBioPortal
IDH2 p.R172K substitution	DIFG	DriverHotspotActionable	2.3%	cBioPortal, TCGA Pan-Cancer Atlas
IDH1 p.R132G substitution	DIFG	DriverHotspotActionable	2.1%	TCGA Pan-Cancer Atlas, cBioPortal
IDH1 p.R132S substitution	DIFG	DriverHotspotActionable	1.8%	cBioPortal, TCGA Pan-Cancer Atlas
EGFR p.R222C substitution	DIFG	DriverHotspotActionable	1.5%	cBioPortal, TCGA Pan-Cancer Atlas
EGFR p.A289T substitution	DIFG	DriverHotspotActionable	1.5%	cBioPortal, TCGA Pan-Cancer Atlas
EGFR p.G598V substitution	DIFG	DriverHotspotActionable	1.2%	TCGA Pan-Cancer Atlas, cBioPortal
EGFR p.A289V substitution	DIFG	DriverHotspotActionable	1.2%	TCGA Pan-Cancer Atlas, cBioPortal
EGFR p.A289D substitution	DIFG	DriverHotspotActionable	1.3%	cBioPortal, TCGA Pan-Cancer Atlas
PIK3CA p.G118D substitution	DIFG	DriverHotspotActionable	0.78%	TCGA Pan-Cancer Atlas, cBioPortal
PIK3CA p.E110del deletion	DIFG	DriverHotspotActionable	0.78%	cBioPortal, TCGA Pan-Cancer Atlas
PIK3CA p.H1047R substitution	DIFG	DriverHotspotActionable	0.78%	TCGA Pan-Cancer Atlas, cBioPortal
EGFR p.H304Y substitution	DIFG	DriverHotspotActionable	0.76%	cBioPortal, TCGA Pan-Cancer Atlas
EGFR p.R252C substitution	DIFG	DriverHotspotActionable	0.58%	TCGA Pan-Cancer Atlas, cBioPortal
EGFR p.L62R substitution	DIFG	DriverHotspotActionable	0.58%	TCGA Pan-Cancer Atlas, cBioPortal
IDH2 p.R172M substitution	DIFG	DriverHotspotActionable	0.58%	cBioPortal, TCGA Pan-Cancer Atlas
PIK3CA p.E453K substitution	DIFG	DriverHotspotActionable	0.58%	cBioPortal, TCGA Pan-Cancer Atlas
PIK3CA p.E453del deletion	DIFG	DriverHotspotActionable	0.58%	cBioPortal, TCGA Pan-Cancer Atlas
PIK3CA p.M1043V substitution	DIFG	DriverHotspotActionable	0.58%	TCGA Pan-Cancer Atlas, cBioPortal
EGFR p.G598A substitution	DIFG	DriverHotspotActionable	0.50%	cBioPortal, TCGA Pan-Cancer Atlas
EGFR p.T363I substitution	DIFG	DriverHotspotActionable	0.50%	cBioPortal, TCGA Pan-Cancer Atlas
KRAS p.G12D substitution	DIFG	DriverHotspotActionable	0.50%	cBioPortal, TCGA Pan-Cancer Atlas
PIK3CA p.R38H substitution	DIFG	DriverHotspotActionable	0.50%	cBioPortal, TCGA Pan-Cancer Atlas
PDGFRA p.E229K substitution	DIFG	DriverHotspotActionable	0.50%	cBioPortal, TCGA Pan-Cancer Atlas
PIK3CA p.E81K substitution	DIFG	DriverHotspotActionable	0.50%	cBioPortal, TCGA Pan-Cancer Atlas
EGFR p.R252P substitution	DIFG	DriverHotspotActionable	0.39%	TCGA Pan-Cancer Atlas, cBioPortal
EGFR p.R108K substitution	DIFG	DriverHotspotActionable	0.39%	TCGA Pan-Cancer Atlas, cBioPortal
IDH2 p.R172G substitution	DIFG	DriverHotspotActionable	0.39%	cBioPortal, TCGA Pan-Cancer Atlas
IDH2 p.R172W substitution	DIFG	DriverHotspotActionable	0.39%	cBioPortal, TCGA Pan-Cancer Atlas
PIK3CA p.E542K substitution	DIFG	DriverHotspotActionable	0.39%	TCGA Pan-Cancer Atlas, cBioPortal
PIK3CA p.K111E substitution	DIFG	DriverHotspotActionable	0.39%	cBioPortal, TCGA Pan-Cancer Atlas
BRAF p.G596D substitution	DIFG	DriverHotspotActionable	0.25%	cBioPortal, TCGA Pan-Cancer Atlas
EGFR p.P596R substitution	DIFG	DriverHotspotActionable	0.25%	cBioPortal, TCGA Pan-Cancer Atlas
EGFR p.P596S substitution	DIFG	DriverHotspotActionable	0.25%	cBioPortal, TCGA Pan-Cancer Atlas
EGFR p.H773_V774dup insertion	DIFG	DriverHotspotActionable	0.25%	cBioPortal, TCGA Pan-Cancer Atlas
EGFR p.L861Q substitution	DIFG	DriverHotspotActionable	0.25%	cBioPortal, TCGA Pan-Cancer Atlas
EGFR p.R108G substitution	DIFG	DriverHotspotActionable	0.25%	cBioPortal, TCGA Pan-Cancer Atlas
FGFR3 p.K650E substitution	DIFG	DriverHotspotActionable	0.25%	cBioPortal, TCGA Pan-Cancer Atlas
PIK3CA p.N345K substitution	DIFG	DriverHotspotActionable	0.25%	cBioPortal, TCGA Pan-Cancer Atlas