Cancer slice

Liver Hepatocellular Carcinoma (TCGA, PanCancer Atlas)

135 records, 16 actionable signals, and 134 hotspot records in this source-aligned cancer slice.

Variant	Cancer	Evidence	Frequency	Sources
IDH1 p.R132C substitution	HCC	DriverHotspotActionable	0.82%	cBioPortal, TCGA Pan-Cancer Atlas
EGFR p.A767_V769dup insertion	HCC	DriverHotspotActionable	0.55%	cBioPortal, TCGA Pan-Cancer Atlas
KRAS p.G12D substitution	HCC	DriverHotspotActionable	0.55%	cBioPortal, TCGA Pan-Cancer Atlas
PIK3CA p.H1047L substitution	HCC	DriverHotspotActionable	0.55%	cBioPortal, TCGA Pan-Cancer Atlas
PIK3CA p.H1047R substitution	HCC	DriverHotspotActionable	0.55%	cBioPortal, TCGA Pan-Cancer Atlas
KRAS p.G12C substitution	HCC	DriverHotspotActionable	0.27%	cBioPortal, TCGA Pan-Cancer Atlas
KRAS p.G13D substitution	HCC	DriverHotspotActionable	0.27%	cBioPortal, TCGA Pan-Cancer Atlas
IDH1 p.R132G substitution	HCC	DriverHotspotActionable	0.27%	cBioPortal, TCGA Pan-Cancer Atlas
IDH2 p.R172K substitution	HCC	DriverHotspotActionable	0.27%	cBioPortal, TCGA Pan-Cancer Atlas
IDH2 p.R172S substitution	HCC	DriverHotspotActionable	0.27%	cBioPortal, TCGA Pan-Cancer Atlas
PIK3CA p.E542K substitution	HCC	DriverHotspotActionable	0.27%	cBioPortal, TCGA Pan-Cancer Atlas
PIK3CA p.T1052K substitution	HCC	DriverHotspotActionable	0.27%	cBioPortal, TCGA Pan-Cancer Atlas
PIK3CA p.R38H substitution	HCC	DriverHotspotActionable	0.27%	cBioPortal, TCGA Pan-Cancer Atlas
PIK3CA p.E726K substitution	HCC	DriverHotspotActionable	0.27%	cBioPortal, TCGA Pan-Cancer Atlas
PIK3CA p.P471L substitution	HCC	DriverHotspotActionable	0.27%	cBioPortal, TCGA Pan-Cancer Atlas
PIK3CA p.E545A substitution	HCC	DriverHotspotActionable	0.27%	cBioPortal, TCGA Pan-Cancer Atlas
CTNNB1 p.S45P substitution	HCC	DriverHotspot	3.0%	cBioPortal, TCGA Pan-Cancer Atlas
TP53 p.R249S substitution	HCC	DriverHotspot	3.0%	cBioPortal, TCGA Pan-Cancer Atlas
CTNNB1 p.D32G substitution	HCC	DriverHotspot	1.9%	cBioPortal, TCGA Pan-Cancer Atlas
CTNNB1 p.K335I substitution	HCC	DriverHotspot	1.6%	cBioPortal, TCGA Pan-Cancer Atlas
CTNNB1 p.S33C substitution	HCC	DriverHotspot	1.6%	cBioPortal, TCGA Pan-Cancer Atlas
CTNNB1 p.T41A substitution	HCC	DriverHotspot	1.4%	cBioPortal, TCGA Pan-Cancer Atlas
CTNNB1 p.D32V substitution	HCC	DriverHotspot	1.4%	cBioPortal, TCGA Pan-Cancer Atlas
CTNNB1 p.S33P substitution	HCC	DriverHotspot	1.4%	cBioPortal, TCGA Pan-Cancer Atlas
CTNNB1 p.H36P substitution	HCC	DriverHotspot	1.4%	cBioPortal, TCGA Pan-Cancer Atlas
CTNNB1 p.S45F substitution	HCC	DriverHotspot	1.1%	cBioPortal, TCGA Pan-Cancer Atlas
GNAS p.R201C substitution	HCC	DriverHotspot	1.1%	cBioPortal, TCGA Pan-Cancer Atlas
TP53 p.H193R substitution	HCC	DriverHotspot	1.1%	cBioPortal, TCGA Pan-Cancer Atlas
CTNNB1 p.S45Y substitution	HCC	DriverHotspot	0.82%	cBioPortal, TCGA Pan-Cancer Atlas
CTNNB1 p.S33Y substitution	HCC	DriverHotspot	0.82%	cBioPortal, TCGA Pan-Cancer Atlas
CTNNB1 p.I35S substitution	HCC	DriverHotspot	0.82%	cBioPortal, TCGA Pan-Cancer Atlas
CTNNB1 p.D32N substitution	HCC	DriverHotspot	0.82%	cBioPortal, TCGA Pan-Cancer Atlas
TP53 p.V157F substitution	HCC	DriverHotspot	0.82%	cBioPortal, TCGA Pan-Cancer Atlas
TP53 p.R248Q substitution	HCC	DriverHotspot	0.82%	cBioPortal, TCGA Pan-Cancer Atlas
CTNNB1 p.T41I substitution	HCC	DriverHotspot	0.55%	cBioPortal, TCGA Pan-Cancer Atlas
CTNNB1 p.S37F substitution	HCC	DriverHotspot	0.55%	cBioPortal, TCGA Pan-Cancer Atlas
ARID1A p.Q1142* substitution	HCC	DriverHotspot	0.55%	cBioPortal, TCGA Pan-Cancer Atlas
CTNNB1 p.G34E substitution	HCC	DriverHotspot	0.55%	cBioPortal, TCGA Pan-Cancer Atlas
CTNNB1 p.D32Y substitution	HCC	DriverHotspot	0.55%	cBioPortal, TCGA Pan-Cancer Atlas
CTNNB1 p.S33F substitution	HCC	DriverHotspot	0.55%	cBioPortal, TCGA Pan-Cancer Atlas