Variant dossier
IDH2 p.R172K
Static provenance dossier for a highlighted variant. Use the linked Explore state to compare related records across the full catalog.
DriverHotspotActionable
IDH2 p.R172K
No mechanism summary is present in the seed catalog for this record.
0.27%
1
2
- Coordinate
- GRCh37 chr15:90,631,838
- Cancer types
- HCC Liver Hepatocellular Carcinoma (TCGA, PanCancer Atlas)
- Pathway
- Not reported
- Therapy context
- Enasidenib
- Clinical annotation
- N/A
- Citations
- 29625048, 29596782, 29622463, 29617662, 29625055, 29625050, 30643250, 32214244, 29625049, 29850653 +1
| Variant | Cancer | Evidence | Frequency | Sources |
|---|---|---|---|---|
| IDH1 p.R132H | DIFG | DriverHotspotActionable | 69.6% | TCGA Pan-Cancer Atlas, cBioPortal |
| IDH1 p.R132C | Not reported | DriverHotspotActionable | Not reported | Cancer Hotspots |
| IDH1 p.R132S | Not reported | DriverHotspotActionable | Not reported | Cancer Hotspots |
| IDH1 p.R132G | Not reported | DriverHotspotActionable | Not reported | Cancer Hotspots |
| IDH1 p.R132H | Not reported | DriverHotspotActionable | Not reported | Cancer Hotspots |
| IDH1 p.R132I | Not reported | DriverHotspotActionable | Not reported | Cancer Hotspots |
| IDH1 p.R132L | Not reported | DriverHotspotActionable | Not reported | Cancer Hotspots |
| IDH2 p.R172R | Not reported | DriverHotspotActionable | Not reported | Cancer Hotspots |