Gene dossier

ALK

55 mutation records across 11 cancer labels and 4 source families.

55 actionable20 hotspotsRTK-RAS

Top records

Prioritized variant evidence

Variant	Cancer	Evidence	Frequency	Sources
ALK p.K1003E substitution	UCS	Likely DriverActionable	1.8%	cBioPortal, TCGA Pan-Cancer Atlas
ALK p.G1473R substitution	CHRCC	Likely DriverActionable	1.5%	cBioPortal, TCGA Pan-Cancer Atlas
ALK p.G955W substitution	PLMESO	Likely DriverActionable	1.2%	cBioPortal, TCGA Pan-Cancer Atlas
ALK p.X1172_splice splice	ACC	Likely DriverActionable	1.1%	cBioPortal, TCGA Pan-Cancer Atlas
ALK p.P381Qfs*42 frameshift	ACC	Likely DriverActionable	1.1%	cBioPortal, TCGA Pan-Cancer Atlas
ALK p.R401* substitution	COADREAD	DriverHotspotActionable	0.56%	cBioPortal, TCGA Pan-Cancer Atlas
ALK p.R401Q substitution	BLCA	DriverHotspotActionable	0.24%	cBioPortal, TCGA Pan-Cancer Atlas
ALK p.R401Q substitution	SKCM	DriverHotspotActionable	0.23%	cBioPortal, TCGA Pan-Cancer Atlas
ALK p.R395H substitution	HNSC	DriverHotspotActionable	0.19%	cBioPortal, TCGA Pan-Cancer Atlas
ALK p.R401L substitution	HNSC	DriverHotspotActionable	0.19%	cBioPortal, TCGA Pan-Cancer Atlas
ALK p.R401* substitution	LUAD	DriverHotspotActionable	0.18%	cBioPortal, TCGA Pan-Cancer Atlas
ALK p.R1275* substitution	BRCA	DriverHotspotActionable	0.09%	cBioPortal, TCGA Pan-Cancer Atlas
ALK p.R1275Q substitution	Not reported	DriverHotspotActionable	Not reported	Cancer Hotspots
ALK p.R1275* substitution	Not reported	DriverHotspotActionable	Not reported	Cancer Hotspots
ALK p.R1275L substitution	Not reported	DriverHotspotActionable	Not reported	Cancer Hotspots
ALK p.F1174C substitution	Not reported	DriverHotspotActionable	Not reported	Cancer Hotspots
ALK p.F1174V substitution	Not reported	DriverHotspotActionable	Not reported	Cancer Hotspots
ALK p.F1174L substitution	Not reported	DriverHotspotActionable	Not reported	Cancer Hotspots
ALK p.F1245V substitution	Not reported	DriverHotspotActionable	Not reported	Cancer Hotspots
ALK p.F1245I substitution	Not reported	DriverHotspotActionable	Not reported	Cancer Hotspots
ALK p.R401Q substitution	Not reported	DriverHotspotActionable	Not reported	Cancer Hotspots
ALK p.R401* substitution	Not reported	DriverHotspotActionable	Not reported	Cancer Hotspots
ALK p.R401L substitution	Not reported	DriverHotspotActionable	Not reported	Cancer Hotspots
ALK p.R395R substitution	Not reported	DriverHotspotActionable	Not reported	Cancer Hotspots
ALK p.R395H substitution	Not reported	DriverHotspotActionable	Not reported	Cancer Hotspots
ALK p.Arg1275Gln substitution	UNSPEC	DriverActionable	Not reported	ClinVar
ALK p.Arg1275Gln substitution	UNSPEC	DriverActionable	Not reported	ClinVar
ALK p.Ile1461Val substitution	UNSPEC	VUSActionable	Not reported	ClinVar
ALK p.Ile1461Val substitution	UNSPEC	VUSActionable	Not reported	ClinVar
ALK p.Lys1491Arg substitution	UNSPEC	VUSActionable	Not reported	ClinVar