Gene dossier

KIT

297 mutation records across 13 cancer labels and 4 source families.

297 actionable89 hotspotsRTK-RAS

Top records

Prioritized variant evidence

Variant	Cancer	Evidence	Frequency	Sources
KIT p.D816H substitution	TESTIS	DriverHotspotActionable	2.7%	cBioPortal, TCGA Pan-Cancer Atlas
KIT p.D816Y substitution	TESTIS	DriverHotspotActionable	2.0%	cBioPortal, TCGA Pan-Cancer Atlas
KIT p.D816V substitution	TESTIS	DriverHotspotActionable	2.0%	cBioPortal, TCGA Pan-Cancer Atlas
KIT p.D816V substitution	AML	DriverHotspotActionable	2.0%	cBioPortal, TCGA Pan-Cancer Atlas
KIT p.D851G substitution	UCS	Likely DriverActionable	1.8%	cBioPortal, TCGA Pan-Cancer Atlas
KIT p.P627L substitution	UCS	Likely DriverActionable	1.8%	cBioPortal, TCGA Pan-Cancer Atlas
KIT p.K642E substitution	SKCM	DriverHotspotActionable	1.4%	cBioPortal, TCGA Pan-Cancer Atlas
KIT p.A829P substitution	TESTIS	Likely DriverActionable	1.3%	cBioPortal, TCGA Pan-Cancer Atlas
KIT p.N822K substitution	TESTIS	DriverHotspotActionable	1.3%	cBioPortal, TCGA Pan-Cancer Atlas
KIT p.D9E substitution	PLMESO	Likely DriverActionable	1.2%	cBioPortal, TCGA Pan-Cancer Atlas
KIT p.V559G substitution	THYM	DriverHotspotActionable	0.81%	cBioPortal, TCGA Pan-Cancer Atlas
KIT p.V559A substitution	SKCM	DriverHotspotActionable	0.68%	cBioPortal, TCGA Pan-Cancer Atlas
KIT p.N822Y substitution	TESTIS	DriverHotspotActionable	0.67%	cBioPortal, TCGA Pan-Cancer Atlas
KIT p.W557C substitution	TESTIS	DriverHotspotActionable	0.67%	cBioPortal, TCGA Pan-Cancer Atlas
KIT p.W557G substitution	TESTIS	DriverHotspotActionable	0.67%	cBioPortal, TCGA Pan-Cancer Atlas
KIT p.N822K substitution	TESTIS	DriverHotspotActionable	0.67%	cBioPortal, TCGA Pan-Cancer Atlas
KIT p.G565_T574delinsA deletion	TESTIS	DriverHotspotActionable	0.67%	cBioPortal, TCGA Pan-Cancer Atlas
KIT p.D816Y substitution	AML	DriverHotspotActionable	0.50%	cBioPortal, TCGA Pan-Cancer Atlas
KIT p.L576P substitution	SKCM	DriverHotspotActionable	0.45%	cBioPortal, TCGA Pan-Cancer Atlas
KIT p.R888Q substitution	UCEC	DriverHotspotActionable	0.39%	cBioPortal, TCGA Pan-Cancer Atlas
KIT p.D816V substitution	CESC	DriverHotspotActionable	0.34%	cBioPortal, TCGA Pan-Cancer Atlas
KIT p.K642N substitution	STAD	DriverHotspotActionable	0.23%	cBioPortal, TCGA Pan-Cancer Atlas
KIT p.N822I substitution	SKCM	DriverHotspotActionable	0.23%	cBioPortal, TCGA Pan-Cancer Atlas
KIT p.W557R substitution	SKCM	DriverHotspotActionable	0.23%	cBioPortal, TCGA Pan-Cancer Atlas
KIT p.N822K substitution	SKCM	DriverHotspotActionable	0.23%	cBioPortal, TCGA Pan-Cancer Atlas
KIT p.N822K substitution	LUSC	DriverHotspotActionable	0.21%	cBioPortal, TCGA Pan-Cancer Atlas
KIT p.R888Q substitution	PRAD	DriverHotspotActionable	0.20%	cBioPortal, TCGA Pan-Cancer Atlas
KIT p.R888Q substitution	COADREAD	DriverHotspotActionable	0.19%	cBioPortal, TCGA Pan-Cancer Atlas
KIT p.N822Y substitution	Not reported	DriverHotspotActionable	Not reported	Cancer Hotspots
KIT p.N822I substitution	Not reported	DriverHotspotActionable	Not reported	Cancer Hotspots