Gene dossier
PIK3CA
639 mutation records across 26 cancer labels and 4 source families.
639 actionable544 hotspotsPI3K-AKT
Top records
Prioritized variant evidence
| Variant | Cancer | Evidence | Frequency | Sources |
|---|---|---|---|---|
| PIK3CA p.E545K | CESC | DriverHotspotActionable | 12.7% | cBioPortal, TCGA Pan-Cancer Atlas |
| PIK3CA p.H1047R | BRCA | DriverHotspotActionable | 12.1% | cBioPortal, TCGA Pan-Cancer Atlas |
| PIK3CA p.E542K | CESC | DriverHotspotActionable | 7.9% | cBioPortal, TCGA Pan-Cancer Atlas |
| PIK3CA p.E545K | BLCA | DriverHotspotActionable | 7.1% | cBioPortal, TCGA Pan-Cancer Atlas |
| PIK3CA p.E545K | UCS | DriverHotspotActionable | 7.0% | cBioPortal, TCGA Pan-Cancer Atlas |
| PIK3CA p.H1047R | UCS | DriverHotspotActionable | 7.0% | cBioPortal, TCGA Pan-Cancer Atlas |
| PIK3CA p.R88Q | UCEC | DriverHotspotActionable | 7.0% | cBioPortal, TCGA Pan-Cancer Atlas |
| PIK3CA p.E545K | COADREAD | DriverHotspotActionable | 6.6% | cBioPortal, TCGA Pan-Cancer Atlas |
| PIK3CA p.E545K | BRCA | DriverHotspotActionable | 6.1% | cBioPortal, TCGA Pan-Cancer Atlas |
| PIK3CA p.H1047R | UCEC | DriverHotspotActionable | 5.6% | cBioPortal, TCGA Pan-Cancer Atlas |
| PIK3CA p.E545K | HNSC | DriverHotspotActionable | 5.0% | cBioPortal, TCGA Pan-Cancer Atlas |
| PIK3CA p.E542K | BLCA | DriverHotspotActionable | 4.4% | cBioPortal, TCGA Pan-Cancer Atlas |
| PIK3CA p.E542K | BRCA | DriverHotspotActionable | 4.0% | cBioPortal, TCGA Pan-Cancer Atlas |
| PIK3CA p.E542K | HNSC | DriverHotspotActionable | 3.7% | cBioPortal, TCGA Pan-Cancer Atlas |
| PIK3CA p.H1047R | STAD | DriverHotspotActionable | 3.7% | cBioPortal, TCGA Pan-Cancer Atlas |
| PIK3CA p.G106V | UCS | DriverHotspotActionable | 3.5% | cBioPortal, TCGA Pan-Cancer Atlas |
| PIK3CA p.R108H | UCS | DriverHotspotActionable | 3.5% | cBioPortal, TCGA Pan-Cancer Atlas |
| PIK3CA p.H1047R | COADREAD | DriverHotspotActionable | 3.4% | cBioPortal, TCGA Pan-Cancer Atlas |
| PIK3CA p.E545K | ESCA | DriverHotspotActionable | 3.3% | cBioPortal, TCGA Pan-Cancer Atlas |
| PIK3CA p.E542K | UCEC | DriverHotspotActionable | 3.3% | cBioPortal, TCGA Pan-Cancer Atlas |
| PIK3CA p.E545K | UCEC | DriverHotspotActionable | 2.9% | cBioPortal, TCGA Pan-Cancer Atlas |
| PIK3CA p.R88Q | COADREAD | DriverHotspotActionable | 2.8% | cBioPortal, TCGA Pan-Cancer Atlas |
| PIK3CA p.H1047L | CHOL | DriverHotspotActionable | 2.8% | cBioPortal, TCGA Pan-Cancer Atlas |
| PIK3CA p.E545K | CHOL | DriverHotspotActionable | 2.8% | cBioPortal, TCGA Pan-Cancer Atlas |
| PIK3CA p.E545K | LUSC | DriverHotspotActionable | 2.7% | cBioPortal, TCGA Pan-Cancer Atlas |
| PIK3CA p.E542K | LUSC | DriverHotspotActionable | 2.7% | cBioPortal, TCGA Pan-Cancer Atlas |
| PIK3CA p.H1047R | HNSC | DriverHotspotActionable | 2.5% | cBioPortal, TCGA Pan-Cancer Atlas |
| PIK3CA p.E542K | COADREAD | DriverHotspotActionable | 2.4% | cBioPortal, TCGA Pan-Cancer Atlas |
| PIK3CA p.E545K | STAD | DriverHotspotActionable | 2.3% | cBioPortal, TCGA Pan-Cancer Atlas |
| PIK3CA p.E726K | CESC | DriverHotspotActionable | 2.1% | cBioPortal, TCGA Pan-Cancer Atlas |