Variant dossier
FLT3 p.D835E
Static provenance dossier for a highlighted variant. Use the linked Explore state to compare related records across the full catalog.
DriverHotspotActionable
FLT3 p.D835E
No mechanism summary is present in the seed catalog for this record.
1.0%
2
2
- Coordinate
- GRCh37 chr13:28,592,640
- Cancer types
- AML Acute Myeloid Leukemia (TCGA, PanCancer Atlas)
- Pathway
- Not reported
- Therapy context
- Midostaurin, Gilteritinib
- Clinical annotation
- N/A
- Citations
- 29625048, 29596782, 29622463, 29617662, 29625055, 29625050, 32214244, 29625049, 29850653, 36334560
| Variant | Cancer | Evidence | Frequency | Sources |
|---|---|---|---|---|
| IDH1 p.R132H | DIFG | DriverHotspotActionable | 69.6% | TCGA Pan-Cancer Atlas, cBioPortal |
| IDH1 p.R132C | Not reported | DriverHotspotActionable | Not reported | Cancer Hotspots |
| IDH1 p.R132S | Not reported | DriverHotspotActionable | Not reported | Cancer Hotspots |
| IDH1 p.R132G | Not reported | DriverHotspotActionable | Not reported | Cancer Hotspots |
| IDH1 p.R132H | Not reported | DriverHotspotActionable | Not reported | Cancer Hotspots |
| IDH1 p.R132I | Not reported | DriverHotspotActionable | Not reported | Cancer Hotspots |
| IDH1 p.R132L | Not reported | DriverHotspotActionable | Not reported | Cancer Hotspots |
| IDH2 p.R172R | Not reported | DriverHotspotActionable | Not reported | Cancer Hotspots |