Variant dossier
FLT3 p.Y599_D600insEYEYEYEY
Static provenance dossier for a highlighted variant. Use the linked Explore state to compare related records across the full catalog.
DriverHotspotActionable
FLT3 p.Y599_D600insEYEYEYEY
No mechanism summary is present in the seed catalog for this record.
0.50%
1
2
- Coordinate
- GRCh37 chr13:28,608,256
- Cancer types
- AML Acute Myeloid Leukemia (TCGA, PanCancer Atlas)
- Pathway
- Not reported
- Therapy context
- Midostaurin, Gilteritinib
- Clinical annotation
- N/A
- Citations
- 29625048, 29596782, 29622463, 29617662, 29625055, 29625050, 32214244, 29625049, 29850653, 36334560
| Variant | Cancer | Evidence | Frequency | Sources |
|---|---|---|---|---|
| IDH1 p.R132H | DIFG | DriverHotspotActionable | 69.6% | TCGA Pan-Cancer Atlas, cBioPortal |
| IDH1 p.R132C | Not reported | DriverHotspotActionable | Not reported | Cancer Hotspots |
| IDH1 p.R132S | Not reported | DriverHotspotActionable | Not reported | Cancer Hotspots |
| IDH1 p.R132G | Not reported | DriverHotspotActionable | Not reported | Cancer Hotspots |
| IDH1 p.R132H | Not reported | DriverHotspotActionable | Not reported | Cancer Hotspots |
| IDH1 p.R132I | Not reported | DriverHotspotActionable | Not reported | Cancer Hotspots |
| IDH1 p.R132L | Not reported | DriverHotspotActionable | Not reported | Cancer Hotspots |
| IDH2 p.R172R | Not reported | DriverHotspotActionable | Not reported | Cancer Hotspots |