Cancer slice

Acute Myeloid Leukemia (TCGA, PanCancer Atlas)

122 records, 42 actionable signals, and 88 hotspot records in this source-aligned cancer slice.

Variant	Cancer	Evidence	Frequency	Sources
IDH2 p.R140Q substitution	AML	DriverHotspotActionable	8.5%	cBioPortal, TCGA Pan-Cancer Atlas
IDH1 p.R132C substitution	AML	DriverHotspotActionable	6.0%	cBioPortal, TCGA Pan-Cancer Atlas
FLT3 p.D835Y substitution	AML	DriverHotspotActionable	5.5%	cBioPortal, TCGA Pan-Cancer Atlas
IDH1 p.R132H substitution	AML	DriverHotspotActionable	2.5%	cBioPortal, TCGA Pan-Cancer Atlas
FLT3 p.F594_D600dup insertion	AML	DriverHotspotActionable	2.5%	cBioPortal, TCGA Pan-Cancer Atlas
KIT p.D816V substitution	AML	DriverHotspotActionable	2.0%	cBioPortal, TCGA Pan-Cancer Atlas
IDH2 p.R172K substitution	AML	DriverHotspotActionable	1.5%	cBioPortal, TCGA Pan-Cancer Atlas
FLT3 p.D835E substitution	AML	DriverHotspotActionable	1.0%	cBioPortal, TCGA Pan-Cancer Atlas
KRAS p.G12V substitution	AML	DriverHotspotActionable	1.0%	cBioPortal, TCGA Pan-Cancer Atlas
KRAS p.G12D substitution	AML	DriverHotspotActionable	1.0%	cBioPortal, TCGA Pan-Cancer Atlas
KRAS p.G13D substitution	AML	DriverHotspotActionable	1.0%	cBioPortal, TCGA Pan-Cancer Atlas
FLT3 p.D835H substitution	AML	DriverHotspotActionable	1.0%	cBioPortal, TCGA Pan-Cancer Atlas
FLT3 p.S584_D600dup insertion	AML	DriverHotspotActionable	0.50%	cBioPortal, TCGA Pan-Cancer Atlas
FLT3 p.D835E substitution	AML	DriverHotspotActionable	0.50%	cBioPortal, TCGA Pan-Cancer Atlas
KRAS p.Q61H substitution	AML	DriverHotspotActionable	0.50%	cBioPortal, TCGA Pan-Cancer Atlas
FLT3 p.E604_F605insSPRGGNEYFYVDFREYEYDLKWE insertion	AML	DriverHotspotActionable	0.50%	cBioPortal, TCGA Pan-Cancer Atlas
FLT3 p.D586_E596dup insertion	AML	DriverHotspotActionable	0.50%	cBioPortal, TCGA Pan-Cancer Atlas
FLT3 p.Y597_K602dup insertion	AML	DriverHotspotActionable	0.50%	cBioPortal, TCGA Pan-Cancer Atlas
FLT3 p.R595_E596insDYVDFR insertion	AML	DriverHotspotActionable	0.50%	cBioPortal, TCGA Pan-Cancer Atlas
KRAS p.A59E substitution	AML	DriverHotspotActionable	0.50%	cBioPortal, TCGA Pan-Cancer Atlas
FLT3 p.M578_E598dup insertion	AML	DriverHotspotActionable	0.50%	cBioPortal, TCGA Pan-Cancer Atlas
FLT3 p.E598_Y599insVAYVDFREYE insertion	AML	DriverHotspotActionable	0.50%	cBioPortal, TCGA Pan-Cancer Atlas
FLT3 p.Y599_E604dup insertion	AML	DriverHotspotActionable	0.50%	cBioPortal, TCGA Pan-Cancer Atlas
FLT3 p.L601_K602insNVDFREYEYDL insertion	AML	DriverHotspotActionable	0.50%	cBioPortal, TCGA Pan-Cancer Atlas
FLT3 p.R595_L601dup insertion	AML	DriverHotspotActionable	0.50%	cBioPortal, TCGA Pan-Cancer Atlas
KIT p.D816Y substitution	AML	DriverHotspotActionable	0.50%	cBioPortal, TCGA Pan-Cancer Atlas
FLT3 p.E598_F612dup insertion	AML	DriverHotspotActionable	0.50%	cBioPortal, TCGA Pan-Cancer Atlas
FLT3 p.S584_F605dup insertion	AML	DriverHotspotActionable	0.50%	cBioPortal, TCGA Pan-Cancer Atlas
FLT3 p.E598_Y599insSGSSDNEYFYVDFREYE insertion	AML	DriverHotspotActionable	0.50%	cBioPortal, TCGA Pan-Cancer Atlas
FLT3 p.D593_F594insSPEDNEYFYVD insertion	AML	DriverHotspotActionable	0.50%	cBioPortal, TCGA Pan-Cancer Atlas
FLT3 p.N587_D600dup insertion	AML	DriverHotspotActionable	0.50%	cBioPortal, TCGA Pan-Cancer Atlas
FLT3 p.F594_R595insGTGSSDNEYFYVDF insertion	AML	DriverHotspotActionable	0.50%	cBioPortal, TCGA Pan-Cancer Atlas
FLT3 p.F612_G613insQGFYVDFREYEYDLKWEFPRENLEF insertion	AML	DriverHotspotActionable	0.50%	cBioPortal, TCGA Pan-Cancer Atlas
KRAS p.A146T substitution	AML	DriverHotspotActionable	0.50%	cBioPortal, TCGA Pan-Cancer Atlas
FLT3 p.Y599_D600insPAPQIMSTSTLISENMNIA insertion	AML	DriverHotspotActionable	0.50%	cBioPortal, TCGA Pan-Cancer Atlas
FLT3 p.Y599_D600insEYEYEYEY insertion	AML	DriverHotspotActionable	0.50%	cBioPortal, TCGA Pan-Cancer Atlas
FLT3 p.Y597_E598insAGSSDNEYFYVDFREY insertion	AML	DriverHotspotActionable	0.50%	cBioPortal, TCGA Pan-Cancer Atlas
IDH1 p.R132G substitution	AML	DriverHotspotActionable	0.50%	cBioPortal, TCGA Pan-Cancer Atlas
FLT3 p.S585_F594dup insertion	AML	DriverHotspotActionable	0.50%	cBioPortal, TCGA Pan-Cancer Atlas
IDH2 p.R140L substitution	AML	DriverHotspotActionable	0.50%	cBioPortal, TCGA Pan-Cancer Atlas